Introduction of DISCO study

We have spent six years in collecting DNA and clinical information from over 2000 diagnosed patients with scoliosis and some of their family members. The DISCO study group is committed to interpret the genomic data produced from all the subjects in the study over the coming years, aiming to increase the diagnostic yield, decipher the novel genetic etiology and the disease mechanisms. Our ultimate goal is to provide precise clinical practice guidelines for molecular diagnosis and disease management, genetic counseling, and even therapy to the patients.Our research is originated from early clinical encounters with patients suffering scoliosis disorders. Our investigations into the pathogenesis of scoliosis will advance our understanding of somitogenesis during development and the course of scoliosis conditions. We are trying to unravel the risk factors and potential mechanisms of scoliosis, especially those with vertebral malformations and develop more effective clinical diagnostic strategy and intervention methods based on these discoveries.